Abstract: This paper conducts an in-depth analysis of the current status and challenges of digital transformation in China’s manufacturing industry and emphasizes the pivotal role of industrial intelligent control systems in driving this transformation. By exploring technological innovation, talent empowerment, and management restructuring, the study elucidates the technical architecture, construction methodologies, and synergistic relationship between industrial intelligent control systems and industrial large-scale models. The research highlights that industrial intelligent control systems can effectively address the bottlenecks in manufacturing transformation, accelerate the transition from digitalization to intelligent digitalization, and bolster the global competitiveness of the manufacturing sector.